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A Role for Drosophila ATX2 in Activation of PER Translation and Circadian Behavior

A negative transcriptional feedback loop generates circadian rhythms in Drosophila. PERIOD (PER) is a critical state-variable in this mechanism, and its abundance is tightly regulated. We found that the Drosophila homolog of ATAXIN-2 (ATX2)—an RNA-binding protein implicated in human... Full description

1st Person: Zhang, Yong
Additional Persons: Ling, Jinli; Yuan, Chunyan; Dubruille, Raphaëlle; Emery, Patrick
Source: in Science Vol. 340, No. 6134 (2013), p. 879-882
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Type of Publication: Article
Language: English
Published: 2013
Online: Volltext
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