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Stability, folding dynamics, and long-range conformational transition of the synaptic t-SNARE complex

Synaptic soluble N-ethylmaleimide–sensitive factor attachment protein receptors (SNAREs) couple their stepwise folding to fusion of synaptic vesicles with plasma membranes. In this process, three SNAREs assemble into a stable four-helix bundle. Arguably, the first and rate-limiting step of... Full description

1st Person: Zhang, Xinming
Additional Persons: Rebane, Aleksander A.; Ma, Lu; Li, Feng(李峰); Jiao, Junyi; Qu, Hong; Pincet, Frederic; Rothman, James E.; Zhang, Yongli
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 113, No. 50 (2016), p. E8031-E8040
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Type of Publication: Article
Language: English
Published: 2016
Keywords: t-SNARE complex
SNARE four-helix bundle
SNARE assembly
membrane fusion
optical tweezers
Online: Volltext
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