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Enhancement of β-catenin activity by BIG1 plus BIG2 via Arf activation and cAMP signals

Multifunctional β-catenin, with critical roles in both cell–cell adhesion and Wnt-signaling pathways, was among HeLa cell proteins coimmunoprecipitated by antibodies against brefeldin A-inhibited guanine nucleotide-exchange factors 1 and 2 (BIG1 or BIG2) that activate ADP-ribosylation factors... Full description

1st Person: Li, Chun-Chun
Additional Persons: Le, Kang; Kato, Jiro; Moss, Joel; Vaughan, Martha
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 113, No. 21 (2016), p. 5946-5951
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Type of Publication: Article
Language: English
Published: 2016
Keywords: ADP-ribosylation factor
cell migration
phospholipase D
Online: Volltext
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