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Anabolic actions of Notch on mature bone

Notch controls skeletogenesis, but its role in the remodeling of adult bone remains conflicting. In mature mice, the skeleton can become osteopenic or osteosclerotic depending on the time point at which Notch is activated or inactivated. Using adult EGFP reporter mice, we find that Notch... Full description

1st Person: Liu, Peng verfasserin
Additional Persons: Ping, Yilin verfasserin; Ma, Meng verfasserin; Zhang, Demao verfasserin; Liu, Connie verfasserin; Zaidi, Samir verfasserin; Gao, Song verfasserin; Ji, Yaoting verfasserin; Lou, Feng verfasserin; Yu, Fanyuan verfasserin; Lu, Ping verfasserin; Stachnik, Agnes verfasserin; Bai, Mingru verfasserin; Wei, Chengguo verfasserin; Zhang, Liaoran verfasserin; Wang, Ke verfasserin; Chen, Rong verfasserin; New, Maria I. verfasserin; Rowe, David W. verfasserin; Yuen, Tony verfasserin; Sun, Li verfasserin; Zaidi, Mone verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 113, No. 15 (2016), p. E2152-E2161
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Type of Publication: Article
Language: English
Published: 2016
Keywords: osteoporosis
aging
therapeutic target
skeletal mineralization
Online: Volltext
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