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Luminopsins integrate opto- and chemogenetics by using physical and biological light sources for opsin activation

Luminopsins are fusion proteins of luciferase and opsin that allow interrogation of neuronal circuits at different temporal and spatial resolutions by choosing either extrinsic physical or intrinsic biological light for its activation. Building on previous development of fusions of wild-type... Full description

1st Person: Berglund, Ken verfasserin
Additional Persons: Clissold, Kara verfasserin; Li, Haofang E. verfasserin; Wen, Lei verfasserin; Park, Sung Young verfasserin; Gleixner, Jan verfasserin; Klein, Marguerita E. verfasserin; Lu, Dongye verfasserin; Barter, Joseph W. verfasserin; Rossi, Mark A. verfasserin; Augustine, George J. verfasserin; Yin, Henry H. verfasserin; Hochgeschwender, Ute verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 113, No. 3 (2016), p. E358-E367
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Type of Publication: Article
Language: English
Published: 2016
Keywords: luciferase
bioluminescence
neural circuitry
substantia nigra
hippocampus
Online: Volltext
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