Katalog GES



Ablative Hypofractionated Radiotherapy Normalizes Tumor Vasculature in Lewis Lung Carcinoma Mice Model

Ablative hypofractionated radiotherapy (HFRT) significantly improves the overall survival of inoperable non-small cell lung cancer (NSCLC) patients compared with conventional radiation therapy. However, the radiobiological mechanisms of ablative HFRT remain largely unknown. The purpose of this... Full description

1st Person: Lan, Jie
Additional Persons: Wan, Xiao-Li; Deng, Lei; Xue, Jian-Xin; Wang, Li-Shuai; Meng, Mao-Bin; Ling, Hua; Zhang, Xi; Mo, Xian-Ming; Lua, You
Source: in Radiation Research Vol. 179, No. 4 (2013), p. 458-464
More Articles
Type of Publication: Article
Language: English
Published: 2013
Online: Volltext
  Search for full text
LEADER 02461nma a2200397 c 4500
001 JST124367720
003 DE-601
005 20191119233218.0
007 cr uuu---uuuuu
008 190102s2013 000 0 eng d
024 8 |a 23483501 
035 |a 23483501 
040 |b ger  |c GBVCP 
041 0 |a eng 
100 1 |a Lan, Jie 
245 1 0 |a Ablative Hypofractionated Radiotherapy Normalizes Tumor Vasculature in Lewis Lung Carcinoma Mice Model  |h Elektronische Ressource 
300 |a Online-Ressource 
500 |a Copyright: Copyright © 2013 Radiation Research Society 
520 |a Ablative hypofractionated radiotherapy (HFRT) significantly improves the overall survival of inoperable non-small cell lung cancer (NSCLC) patients compared with conventional radiation therapy. However, the radiobiological mechanisms of ablative HFRT remain largely unknown. The purpose of this study was to investigate the dynamic changes of tumor vessels and perfusion during and after ablative hypofractionated radiotherapy. Lewis lung carcinoma-bearing mice were treated with sham (control) and ablative hypofractionated radiotherapy of 12 Gy in 1 fraction (12 Gy/1F) and 36 Gy in 3 fractions (36 Gy/3F). Tumor microvessel density (MVD), morphology and function were examined at different times after irradiation. The results showed that, compared to the controls the MVD and hypoxia in ablative HFRT groups decreased, which were accompanied by an increase in the number of pericytes and their coverage of vessels. Functional tests revealed that tumor hypoxia and perfusion were improved, especially in the 36 Gy/3F group. Our results revealed that ablative hypofractionated radiotherapy not only repressed MVD and hypoxia, but also increased the vascular perfusion and the number of pericyte-covered vessels, suggesting that ablative HFRT normalized the tumor vasculature. 
611 2 7 |a research-article  |2 gnd 
689 0 0 |A f  |a research-article 
689 0 |5 DE-601 
700 1 |a Wan, Xiao-Li 
700 1 |a Deng, Lei 
700 1 |a Xue, Jian-Xin 
700 1 |a Wang, Li-Shuai 
700 1 |a Meng, Mao-Bin 
700 1 |a Ling, Hua 
700 1 |a Zhang, Xi 
700 1 |a Mo, Xian-Ming 
700 1 |a Lua, You 
773 0 8 |i in  |t Radiation Research  |g Vol. 179, No. 4 (2013), p. 458-464  |q 179:4<458-464  |w (DE-601)JST072825871  |x 1938-5404 
856 4 1 |u http://dx.doi.org/10.1667/RR3116.1  |3 Volltext 
912 |a GBV_JSTOR 
951 |a AR 
952 |d 179  |j 2013  |e 4  |h 458-464 

Similar Items

Cannot find similar records

Library Services

Search Options

Quick links

Orientation