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Ablative Hypofractionated Radiotherapy Normalizes Tumor Vasculature in Lewis Lung Carcinoma Mice Model

Ablative hypofractionated radiotherapy (HFRT) significantly improves the overall survival of inoperable non-small cell lung cancer (NSCLC) patients compared with conventional radiation therapy. However, the radiobiological mechanisms of ablative HFRT remain largely unknown. The purpose of this... Full description

1st Person: Lan, Jie verfasserin
Additional Persons: Wan, Xiao-Li verfasserin; Deng, Lei verfasserin; Xue, Jian-Xin verfasserin; Wang, Li-Shuai verfasserin; Meng, Mao-Bin verfasserin; Ling, Hua verfasserin; Zhang, Xi verfasserin; Mo, Xian-Ming verfasserin; Lua, You verfasserin
Source: in Radiation Research Vol. 179, No. 4 (2013), p. 458-464
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Type of Publication: Article
Language: English
Published: 2013
Online: Volltext
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Summary: Ablative hypofractionated radiotherapy (HFRT) significantly improves the overall survival of inoperable non-small cell lung cancer (NSCLC) patients compared with conventional radiation therapy. However, the radiobiological mechanisms of ablative HFRT remain largely unknown. The purpose of this study was to investigate the dynamic changes of tumor vessels and perfusion during and after ablative hypofractionated radiotherapy. Lewis lung carcinoma-bearing mice were treated with sham (control) and ablative hypofractionated radiotherapy of 12 Gy in 1 fraction (12 Gy/1F) and 36 Gy in 3 fractions (36 Gy/3F). Tumor microvessel density (MVD), morphology and function were examined at different times after irradiation. The results showed that, compared to the controls the MVD and hypoxia in ablative HFRT groups decreased, which were accompanied by an increase in the number of pericytes and their coverage of vessels. Functional tests revealed that tumor hypoxia and perfusion were improved, especially in the 36 Gy/3F group. Our results revealed that ablative hypofractionated radiotherapy not only repressed MVD and hypoxia, but also increased the vascular perfusion and the number of pericyte-covered vessels, suggesting that ablative HFRT normalized the tumor vasculature.
Item Description: Copyright: Copyright © 2013 Radiation Research Society
Physical Description: Online-Ressource
ISSN: 1938-5404

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