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Single-molecule analysis reveals widespread structural variation in multiple myeloma

Multiple myeloma (MM), a malignancy of plasma cells, is characterized by widespread genomic heterogeneity and, consequently, differences in disease progression and drug response. Although recent large-scale sequencing studies have greatly improved our understanding of MM genomes, our knowledge... Full description

1st Person: Gupta, Aditya verfasserin
Additional Persons: Place, Michael verfasserin; Goldstein, Steven verfasserin; Sarkar, Deepayan verfasserin; Zhou, Shiguo verfasserin; Potamousis, Konstantinos verfasserin; Kim, Jaehyup verfasserin; Flanagan, Claire verfasserin; Li, Yang verfasserin; Newton, Michael A. verfasserin; Callander, Natalie S. verfasserin; Hematti, Peiman verfasserin; Bresnick, Emery H. verfasserin; Ma, Jian verfasserin; Asimakopoulos, Fotis verfasserin; Schwartz, David C. verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 112, No. 25 (2015), p. 7689-7694
More Articles
Type of Publication: Article
Language: English
Published: 2015
Keywords: structural variation
copy number
multiple myeloma
optical mapping
DNA sequencing
Online: Volltext
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