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Mx1 and Mx2 key antiviral proteins are surprisingly lost in toothed whales

Viral outbreaks in dolphins and otherDelphinoideafamily members warrant investigation into the integrity of the cetacean immune system. The dynamin-like GTPase genes Myxovirus 1 (Mx1) andMx2defend mammals against a broad range of viral infections. Loss of Mx1 function in human and mice enhances... Full description

1st Person: Braun, Benjamin A. verfasserin
Additional Persons: Marcovitz, Amir verfasserin; Camp, J. Gray verfasserin; Jia, Robin verfasserin; Bejerano, Gill verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 112, No. 26 (2015), p. 8036-8040
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Type of Publication: Article
Language: English
Published: 2015
Keywords: gene loss
Mx genes
cetaceans
immune system
toothed whales
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