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Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

A coding polymorphism (Thr300Ala) in the essential autophagy gene, autophagy related 16-like 1 (ATG16L1), confers increased risk for the development of Crohn disease, although the mechanisms by which single disease-associated polymorphisms contribute to pathogenesis have been difficult to dissect... Full description

1st Person: Lassen, Kara G.
Additional Persons: Kuballa, Petric; Conway, Kara L.; Patel, Khushbu K.; Becker, Christine E.; Peloquin, Joanna M.; Villablanca, Eduardo J.; Norman, Jason M.; Liu, Ta-Chiang; Heath, Robert J.; Becker, Morgan L.; Fagbami, Lola; Horn, Heiko; Mercer, Johnathan; Yilmaz, Omer H.; Jaffe, Jacob D.; Shamji, Alykhan F.; Bhan, Atul K.; Carr, Steven A.; Daly, Mark J.; Virgin, Herbert W.; Schreiber, Stuart L.; Stappenbeck, Thaddeus S.; Xavier, Ramnik J.
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 111, No. 21 (2014), p. 7741-7746
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Type of Publication: Article
Language: English
Published: 2014
Online: Volltext
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