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Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

A coding polymorphism (Thr300Ala) in the essential autophagy gene, autophagy related 16-like 1 (ATG16L1), confers increased risk for the development of Crohn disease, although the mechanisms by which single disease-associated polymorphisms contribute to pathogenesis have been difficult to dissect... Full description

1st Person: Lassen, Kara G.
Additional Persons: Kuballa, Petric verfasserin; Conway, Kara L. verfasserin; Patel, Khushbu K. verfasserin; Becker, Christine E. verfasserin; Peloquin, Joanna M. verfasserin; Villablanca, Eduardo J. verfasserin; Norman, Jason M. verfasserin; Liu, Ta-Chiang verfasserin; Heath, Robert J. verfasserin; Becker, Morgan L. verfasserin; Fagbami, Lola verfasserin; Horn, Heiko verfasserin; Mercer, Johnathan verfasserin; Yilmaz, Omer H. verfasserin; Jaffe, Jacob D. verfasserin; Shamji, Alykhan F. verfasserin; Bhan, Atul K. verfasserin; Carr, Steven A. verfasserin; Daly, Mark J. verfasserin; Virgin, Herbert W. verfasserin; Schreiber, Stuart L. verfasserin; Stappenbeck, Thaddeus S. verfasserin; Xavier, Ramnik J. verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 111, No. 21 (2014), p. 7741-7746
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Type of Publication: Article
Language: English
Published: 2014
Keywords: research-article
Online: Volltext
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