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Neuronal prostaglandin E₂ receptor subtype EP3 mediates antinociception during inflammation

The pain mediator prostaglandin E₂ (PGE₂) sensitizes nociceptive pathways through EP2 and EP4 receptors, which are coupled to Gs proteins and increase cAMP. However, PGE₂ also activates EP3 receptors, and the major signaling pathway of the EP3 receptor splice variants uses inhibition of... Full description

1st Person: Natura, Gabriel
Additional Persons: Bär, Karl-Jürgen verfasserin; Eitner, Annett verfasserin; Boettger, Michael K. verfasserin; Richter, Frank verfasserin; Hensellek, Susanne verfasserin; Ebersberger, Andrea verfasserin; Leuchtweis, Johannes verfasserin; Maruyama, Takayuki verfasserin; Hofmann, Gunther Olaf verfasserin; Halbhuber, Karl-Jürgen verfasserin; Schaible, Hans-Georg verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 110, No. 33 (2013), p. 13648-13653
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Type of Publication: Article
Language: English
Published: 2013
Keywords: research-article
Online: Volltext
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