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SIRT2 directs the replication stress response through CDK9 deacetylation

Sirtuin 2 (SIRT2) is a sirtuin family deacetylase that directs acetylome signaling, protects genome integrity, and is a murine tumor suppressor. We show that SIRT2 directs replication stress responses by regulating the activity of cyclin-dependent kinase 9 (CDK9), a protein required for recovery... Full description

1st Person: Zhang, Hui
Additional Persons: Park, Seong-Hoon verfasserin; Pantazides, Brooke G. verfasserin; Karpiuk, Oleksandra verfasserin; Warren, Matthew D. verfasserin; Hardy, Claire W. verfasserin; Duong, Due M. verfasserin; Park, So-Jeong verfasserin; Kim, Hyun-Seok verfasserin; Vassilopoulos, Athanassios verfasserin; Seyfried, Nicholas T. verfasserin; Johnsen, Steven A. verfasserin; Gius, David verfasserin; Yu, David S. verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 110, No. 33 (2013), p. 13546-13551
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Type of Publication: Article
Language: English
Published: 2013
Keywords: research-article
Online: Volltext
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