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Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells

TANK-binding kinase 1 (TBK1) has emerged as a novel therapeutic target for unspecified subset of lung cancers. TBK1 reportedly mediates prosurvival signaling by activating NF-κB and AKT. However, we observed that TBK1 knockdown also decreased viability of cells expressing constitutively active... Full description

1st Person: Kim, Jae-Young
Additional Persons: Welsh, Eric A. verfasserin; Oguz, Umut verfasserin; Fang, Bin verfasserin; Bai, Yun verfasserin; Kinose, Fumi verfasserin; Bronk, Crystina verfasserin; Rix, Lily L. Remsing verfasserin; Beg, Amer A. verfasserin; Rix, Uwe verfasserin; Eschrich, Steven A. verfasserin; Koomen, John M. verfasserin; Haura, Eric B. verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 110, No. 30 (2013), p. 12414-12419
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Type of Publication: Article
Language: English
Published: 2013
Keywords: research-article
Online: Volltext
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