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Coexistence of ribbon and helical fibrils originating from hIAPP₂₀₋₂₉ revealed by quantitative nanomechanical atomic force microscopy

Uncontrolled misfolding of proteins leading to the formation of amyloid deposits is associated with more than 40 types of diseases, such as neurodegenerative diseases and type-2 diabetes. These irreversible amyloid fibrils typically assemble in distinct stages. Transitions among the various... Full description

1st Person: Zhang, Shuai
Additional Persons: Andreasen, Maria verfasserin; Nielsen, Jakob T. verfasserin; Liu, Lei verfasserin; Nielsen, Erik H. verfasserin; Song, Jie verfasserin; Ji, Gang verfasserin; Sun, Fei verfasserin; Skrydstrup, Troels verfasserin; Besenbacher, Flemming verfasserin; Nielsen, Niels C. verfasserin; Otzen, Daniel E. verfasserin; Dong, Mingdong verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 110, No. 8 (2013), p. 2798-2803
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Type of Publication: Article
Language: English
Published: 2013
Keywords: research-article
Online: Volltext
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