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NF-κB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-κB in immune-mediated diseases

Activation of the nuclear transcription factor κB (NF-κB) regulates the expression of inflammatory genes crucially involved in the pathogenesis of inflammatory diseases. NF-κB governs the expression of adhesion molecules that play a pivotal role in leukocyte–endothelium interactions. We... Full description

1st Person: Sehnert, Bettina
Additional Persons: Burkhardt, Harald verfasserin; Wessels, Johannes T. verfasserin; Schröder, Agnes verfasserin; May, Michael J. verfasserin; Vestweber, Dietmar verfasserin; Zwerina, Jochen verfasserin; Warnatz, Klaus verfasserin; Nimmerjahn, Falk verfasserin; Schett, Georg verfasserin; Dübel, Stefan verfasserin; Voll, Reinhard Edmund verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 110, No. 41 (2013), p. 16556-16561
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Type of Publication: Article
Language: English
Published: 2013
Keywords: research-article
Online: Volltext
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