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M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability

UHRF1 (Ubiquitin-like, with PHD and RING finger domains 1) plays an important role in DNA CpG methylation, heterochromatin function and gene expression. Overexpression of UHRF1 has been suggested to contribute to tumorigenesis. However, regulation of UHRF1 is largely unknown. Here we show that... Full description

1st Person: Ma, Honghui
Additional Persons: Chen, Hao verfasserin; Guo, Xue verfasserin; Wang, Zhentian verfasserin; Sowa, Mathew E. verfasserin; Zheng, Lijuan verfasserin; Hu, Shibin verfasserin; Zeng, Pingyao verfasserin; Guo, Rui verfasserin; Diao, Jianbo verfasserin; Lan, Fei verfasserin; Harper, J. Wade verfasserin; Shi, Yujiang Geno verfasserin; Xu, Yanhui verfasserin; Shi, Yang verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 109, No. 13 (2012), p. 4828-4833
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Type of Publication: Article
Language: English
Published: 2012
Keywords: research-article
Online: Volltext
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