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Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling

Increased flux through the glycerolipid synthesis pathway impairs the ability of insulin to inhibit hepatic gluconeogenesis, but the exact mechanism remains unknown. To determine the mechanism by which glycerolipids impair insulin signaling, we overexpressed glycerol-3-phosphate acyltransferase-1... Full description

1st Person: Zhang, Chongben
Additional Persons: Wendel, Angela A.; Keogh, Matthew R.; Harris, Thurl E.; Chen, Jie; Coleman, Rosalind A.
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 109, No. 5 (2012), p. 1667-1672
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Type of Publication: Article
Language: English
Published: 2012
Online: Volltext
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