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Implantation of Vascular Grafts Lined with Genetically Modified Endothelial Cells

The possibility of using the vascular endothelial cell as a target for gene replacement therapy was explored. Recombinant retroviruses were used to transduce the lacZ gene into endothelial cells harvested from mongrel dogs. Prosthetic vascular grafts seeded with the genetically modified cells... Full description

1st Person: Wilson, James M.
Additional Persons: Birinyi, Louis K. verfasserin; Salomon, Robert N. verfasserin; Libby, Peter verfasserin; Callow, Allan D. verfasserin; Mulligan, Richard C. verfasserin
Source: in Science Vol. 244, No. 4910 (1989), p. 1344-1346
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Type of Publication: Article
Language: English
Published: 1989
Keywords: research-article
Online: Volltext
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