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Cancer Regression and Autoimmunity in Patients after Clonal Repopulation with Antitumor Lymphocytes

We report here the adoptive transfer, to patients with metastatic melanoma, of highly selected tumor-reactive T cells directed against overexpressed self-derived differentiation antigens after a nonmyeloablative conditioning regimen. This approach resulted in the persistent clonal repopulation of... Full description

1st Person: Dudley, Mark E.
Additional Persons: Wunderlich, John R.; Robbins, Paul F.; Yang, James C.; Hwu, Patrick; Schwartzentruber, Douglas J.; Topalian, Suzanne L.; Sherry, Richard; Restifo, Nicholas P.; Hubicki, Amy M.; Robinson, Michael R.; Raffeld, Mark; Duray, Paul; Seipp, Claudia A.; Rogers-Freezer, Linda; Morton, Kathleen E.; Mavroukakis, Sharon A.; White, Donald E.; Rosenberg, Steven A.
Source: in Science Vol. 298, No. 5594 (2002), p. 850-854
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Type of Publication: Article
Language: English
Published: 2002
Online: Volltext
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