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Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

The immunosuppressant rapamycin interferes with G$_1$-phase progression in lymphoid and other cell types by inhibiting the function of the mammalian target of rapamycin (mTOR). mTOR was determined to be a terminal kinase in a signaling pathway that couples mitogenic stimulation to the... Full description

1st Person: Brunn, Gregory J.
Additional Persons: Hudson, Christine C. verfasserin; Sekulić, Aleksandar verfasserin; Williams, Josie M. verfasserin; Hosoi, Hajime verfasserin; Houghton, Peter J. verfasserin; Lawrence, John C. verfasserin; Abraham, Robert T. verfasserin
Source: in Science Vol. 277, No. 5322 (1997), p. 99-101
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Type of Publication: Article
Language: English
Published: 1997
Keywords: research-article
Online: Volltext
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