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A Null Mutation in Human APOC3 Confers a Favorable Plasma Lipid Profile and Apparent Cardioprotection

Apolipoprotein C-III (apoC-III) inhibits triglyceride hydrolysis and has been implicated in coronary artery disease. Through a genome-wide association study, we have found that about 5% of the Lancaster Amish are heterozygous carriers of a null mutation (R19X) in the gene encoding apoC-III... Full description

1st Person: Pollin, Toni I.
Additional Persons: Damcott, Coleen M. verfasserin; Shen, Haiqing verfasserin; Ott, Sandra H. verfasserin; Shelton, John verfasserin; Horenstein, Richard B. verfasserin; Post, Wendy verfasserin; McLenithan, John C. verfasserin; Bielak, Lawrence F. verfasserin; Peyser, Patricia A. verfasserin; Mitchell, Braxton D. verfasserin; Miller, Michael verfasserin; O'Connell, Jeffrey R. verfasserin; Shuldiner, Alan R. verfasserin
Source: in Science Vol. 322, No. 5908 (2008), p. 1702-1705
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Type of Publication: Article
Language: English
Published: 2008
Keywords: research-article
Online: Volltext
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