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Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

Aneuploidy, an incorrect number of chromosomes, is the leading cause of miscarriages and mental retardation in humans and is a hallmark of cancer. We examined the effects of aneuploidy on primary mouse cells by generating a series of cell lines that carry an extra copy of one of four mouse... Full description

1st Person: Williams, Bret R.
Additional Persons: Prabhu, Vineet R. verfasserin; Hunter, Karen E. verfasserin; Glazier, Christina M. verfasserin; Whittaker, Charles A. verfasserin; Housman, David E. verfasserin; Amon, Angelika verfasserin
Source: in Science Vol. 322, No. 5902 (2008), p. 703-709
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Type of Publication: Article
Language: English
Published: 2008
Keywords: research-article
Online: Volltext
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