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Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors

The localization of substance P in brain regions that coordinate stress responses and receive convergent monoaminergic innervation suggested that substance P antagonists might have psychotherapeutic properties. Like clinically used antidepressant and anxiolytic drugs, substance P antagonists... Full description

1st Person: Kramer, Mark S.
Additional Persons: Cutler, Neal verfasserin; Feighner, John verfasserin; Shrivastava, Ram verfasserin; Carman, John verfasserin; Sramek, John J. verfasserin; Reines, Scott A. verfasserin; Liu, Guanghan verfasserin; Snavely, Duane verfasserin; Wyatt-Knowles, Edwina verfasserin; Hale, Jeffrey J. verfasserin; Mills, Sander G. verfasserin; MacCoss, Malcolm verfasserin; Swain, Christopher J. verfasserin; Harrison, Timothy verfasserin; Hill, Raymond G. verfasserin; Hefti, Franz verfasserin; Scolnick, Edward M. verfasserin; Cascieri, Margaret A. verfasserin; Chicchi, Gary G. verfasserin; Sadowski, Sharon verfasserin; Williams, Angela R. verfasserin; Hewson, Louise verfasserin; Smith, David verfasserin; Carlson, Emma J. verfasserin; Hargreaves, Richard J. verfasserin
Source: in Science Vol. 281, No. 5383 (1998), p. 1640-1645
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Type of Publication: Article
Language: English
Published: 1998
Keywords: research-article
Online: Volltext
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