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COOH-Terminal--Modified Interleukin-3 Is Retained Intracellularly and Stimulates Autocrine Growth

Autocrine growth due to dysregulated growth factor production may have a role in the development of neoplasia. Whether autocrine growth is stimulated by growth factor secretion in an autocrine loop or by intracellular binding of the growth factor to a receptor has been unclear. The... Full description

1st Person: Dunbar, Cynthia E.
Additional Persons: Browder, Timothy M. verfasserin; Abrams, John S. verfasserin; Nienhuis, Arthur W. verfasserin
Source: in Science Vol. 245, No. 4925 (1989), p. 1493-1496
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Type of Publication: Article
Language: English
Published: 1989
Keywords: research-article
Online: Volltext
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