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Correction of CD18-Deficient Lymphocytes by Retrovirus-Mediated Gene Transfer

Leukocyte adhesion deficiency (LAD) is an inherited disorder of leukocyte function caused by derangements in CD 18 expression. The genetic and functional abnormalities in a lymphocyte cell line from a patient with LAD have been corrected by retrovirusmediated transduction of a functional CD18... Full description

1st Person: Wilson, James M.
Additional Persons: Ping, April Joy; Krauss, John C.; Mayo-Bond, Laura; Rogers, Clare E.; Anderson, Donald C.; Todd, Robert F.
Source: in Science Vol. 248, No. 4961 (1990), p. 1413-1416
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Type of Publication: Article
Language: English
Published: 1990
Online: Volltext
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