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Correction of CD18-Deficient Lymphocytes by Retrovirus-Mediated Gene Transfer

Leukocyte adhesion deficiency (LAD) is an inherited disorder of leukocyte function caused by derangements in CD 18 expression. The genetic and functional abnormalities in a lymphocyte cell line from a patient with LAD have been corrected by retrovirusmediated transduction of a functional CD18... Full description

1st Person: Wilson, James M.
Additional Persons: Ping, April Joy verfasserin; Krauss, John C. verfasserin; Mayo-Bond, Laura verfasserin; Rogers, Clare E. verfasserin; Anderson, Donald C. verfasserin; Todd, Robert F. verfasserin
Source: in Science Vol. 248, No. 4961 (1990), p. 1413-1416
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Type of Publication: Article
Language: English
Published: 1990
Keywords: research-article
Online: Volltext
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100 1 |a Wilson, James M. 
245 1 0 |a Correction of CD18-Deficient Lymphocytes by Retrovirus-Mediated Gene Transfer  |h Elektronische Ressource 
300 |a Online-Ressource 
500 |a Copyright: Copyright 1990 American Association for the Advancement of Science 
520 |a Leukocyte adhesion deficiency (LAD) is an inherited disorder of leukocyte function caused by derangements in CD 18 expression. The genetic and functional abnormalities in a lymphocyte cell line from a patient with LAD have been corrected by retrovirusmediated transduction of a functional CD18 gene. Lymphocytes from patients with LAD were exposed to CD 18-expressing retrovirus and enriched for cells that express CDlla and CD18 (LFA-1) on the cell surface. Molecular and functional analyses of these cells revealed (i) one copy of proviral sequence per cell, (ii) viral-directed CD18 RNA that exceeded normal endogenous levels, (iii) normal quantities of CD11a and CD18 protein on the cell surface, and (iv) reconstitution of LFA-l-dependent adhesive function. 
653 |a research-article 
700 1 |a Ping, April Joy  |e verfasserin  |4 aut 
700 1 |a Krauss, John C.  |e verfasserin  |4 aut 
700 1 |a Mayo-Bond, Laura  |e verfasserin  |4 aut 
700 1 |a Rogers, Clare E.  |e verfasserin  |4 aut 
700 1 |a Anderson, Donald C.  |e verfasserin  |4 aut 
700 1 |a Todd, Robert F.  |e verfasserin  |4 aut 
773 0 8 |i in  |t Science  |g Vol. 248, No. 4961 (1990), p. 1413-1416  |q 248:4961<1413-1416  |w (DE-601)JST078179041  |x 1095-9203 
856 4 1 |u https://www.jstor.org/stable/2874457  |3 Volltext 
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951 |a AR 
952 |d 248  |j 1990  |e 4961  |h 1413-1416 

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