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Structure of the Immature Dengue Virus at Low pH Primes Proteolytic Maturation

Intracellular cleavage of immature flaviviruses is a critical step in assembly that generates the membrane fusion potential of the E glycoprotein. With cryo--electron microscopy we show that the immature dengue particles undergo a reversible conformational change at low pH that renders them... Full description

1st Person: Yu, I-Mei
Additional Persons: Zhang, Wei verfasserin; Holdaway, Heather A. verfasserin; Li, Long verfasserin; Kostyuchenko, Victor A. verfasserin; Chipman, Paul R. verfasserin; Kuhn, Richard J. verfasserin; Rossmann, Michael G. verfasserin; Chen, Jue verfasserin
Source: in Science Vol. 319, No. 5871 (2008), p. 1834-1837
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Type of Publication: Article
Language: English
Published: 2008
Keywords: research-article
Online: Volltext
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