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From combinatorial peptide selection to drug prototype (II): Targeting the epidermal growth factor receptor pathway

The epidermal growth factor receptor (EGFR), a tyrosine kinase, is central to human tumorigenesis. Typically, three classes of drugs inhibit tyrosine kinase pathways: blocking antibodies, small kinase inhibitors, and soluble ligand receptor traps/decoys. Only the first two types of EGFR-binding... Full description

1st Person: Cardó-Vila, Marina
Additional Persons: Giordano, Ricardo J.; Sidman, Richard L.; Bronk, Lawrence F.; Fan, Zhen; Mendelsohn, John; Arap, Wadih; Pasqualini, Renata
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 107, No. 11 (2010), p. 5118-5123
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Type of Publication: Article
Language: English
Published: 2010
Online: Volltext
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