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Temporary Amelioration of Hyperlipidemia in Low Density Lipoprotein Receptor-Deficient Rabbits Transplanted with Genetically Modified Hepatocytes

Familial hypercholesterolemia is an inherited disease in humans that is associated with coronary artery disease and is caused by a deficiency of the receptor that mediates the internalization of low density lipoprotein (LDL). We have used an animal model for familial hypercholesterolemia, the... Full description

1st Person: Wilson, James M.
Additional Persons: Chowdhury, N. Roy verfasserin; Grossman, Mariann verfasserin; Wajsman, Renata verfasserin; Epstein, Adam verfasserin; Mulligan, Richard C. verfasserin; Chowdhury, J. Roy verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 87, No. 21 (1990), p. 8437-8441
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Type of Publication: Article
Language: English
Published: 1990
Keywords: research-article
Familial Hypercholesterolemia
Hepatocyte Transplantation
Gene Therapy
Online: Volltext
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