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Correction of the Genetic Defect in Hepatocytes from the Watanabe Heritable Hyperlipidemic Rabbit

Familial hypercholesterolemia is an inherited disease in humans that is caused by a defect in the receptor for low density lipoproteins (LDLR). The existence of an animal model for this disease, the Watanabe heritable hyperlipidemic (WHHL) rabbit, makes it an attractive candidate for developing... Full description

1st Person: Wilson, James M.
Additional Persons: Johnston, David E. verfasserin; Jefferson, Douglas M. verfasserin; Mulligan, Richard C. verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 85, No. 12 (1988), p. 4421-4425
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Type of Publication: Article
Language: English
Published: 1988
Keywords: research-article
Genetics
Retroviral Vector
Gene Transfer
Familial Hypercholesterolemia
Online: Volltext
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