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Mechanisms of HFE-Induced Regulation of Iron Homeostasis: Insights from the W81A HFE Mutation

The mechanisms by which the hereditary hemochromatosis protein, HFE, decreases transferrin-mediated iron uptake were examined. Coimmunoprecipitation studies using solubilized cell extracts demonstrated that transferrin (Tf) competed with HFE for binding to the transferrin receptor (TfR) similar... Full description

1st Person: Zhang, An-Sheng
Additional Persons: Davies, Paige S.; Carlson, Hanqian L.; Enns, Caroline A.
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 100, No. 16 (2003), p. 9500-9505
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Type of Publication: Article
Language: English
Published: 2003
Keywords: Medical Sciences
Online: Volltext
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