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Selective Targeting of Radiation-Resistant Tumor-Initiating Cells

Tumor-initiating cells (TICs) have been shown both experimentally and clinically to be resistant to radiation and chemotherapy, potentially resulting in residual disease that can lead to recurrence. In this study, we demonstrate that TICs isolated from p53 null mouse mammary tumors repair DNA... Full description

1st Person: Zhang, Mei
Additional Persons: Atkinson, Rachel L. verfasserin; Rosen, Jeffrey M. verfasserin; Woude, George F. Vande verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 107, No. 8 (2010), p. 3522-3527
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Type of Publication: Article
Language: English
Published: 2010
Keywords: research-article
Akt and Wnt signaling
DNA damage repair
p53 mouse model
Online: Volltext
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