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Cloning and Sequencing of cDNA Encoding Human DNA Topoisomerase II and Localization of the Gene to Chromosome Region 17q21-22

Two overlapping cDNA clones encoding human DNA topoisomerase II were identified by two independent methods. In one, a human cDNA library in phage λ was screened by hybridization with a mixed oligonucleotide probe encoding a stretch of seven amino acids found in yeast and Drosophila DNA... Full description

1st Person: Tsai-Pflugfelder, Monika
Additional Persons: Liu, Leroy F.; Liu, Angela A.; Tewey, Kathleen M.; Whang-Peng, Jacqueline; Knutsen, Turid; Huebner, Kay; Croce, Carlo M.; Wang, James C.
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 85, No. 19 (1988), p. 7177-7181
More Articles
Type of Publication: Article
Language: English
Published: 1988
Keywords: Biochemistry
Hairpinned Oligonucleotide Probe
Single-Copy Gene
In situ Hybridization
Mouse-Human Hybrids
Online: Volltext
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