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High Blood Pressure Arising from a Defect in Vascular Function

Hypertension, a major cardiovascular risk factor and cause of mortality worldwide, is thought to arise from primary renal abnormalities. However, the etiology of most cases of hypertension remains unexplained. Vascular tone, an important determinant of blood pressure, is regulated by nitric... Full description

1st Person: Michael, Simon K.
Additional Persons: Surks, Howard K. verfasserin; Wang, Yuepeng verfasserin; Zhu, Yan verfasserin; Blanton, Robert verfasserin; Jamnongjit, Michelle verfasserin; Aronovitz, Mark verfasserin; Baur, Wendy verfasserin; Ohtani, Kenichi verfasserin; Wilkerson, Michael K. verfasserin; Bonev, Adrian D. verfasserin; Nelson, Mark T. verfasserin; Karas, Richard H. verfasserin; Mendelsohn, Michael E. verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 105, No. 18 (2008), p. 6702-6707
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Type of Publication: Article
Language: English
Published: 2008
Keywords: research-article
Cyclic nucleotides
Hypertension
Nitric oxide
Vascular biology
Vascular smooth muscle
Online: Volltext
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