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Somatic Activation of Oncogenic Kras in Hematopoietic Cells Initiates a Rapidly Fatal Myeloproliferative Disorder

RAS mutations are common in myeloid malignancies; however, it is not known whether oncogenic RAS can initiate leukemia. We show that expressing mutant K-RasG12Dprotein from the endogenous murine locus rapidly induces a fatal myeloproliferative disorder with 100% penetrance characterized by tissue... Full description

1st Person: Braun, Benjamin S.
Additional Persons: Tuveson, David A. verfasserin; Kong, Namie verfasserin; Le, Doan T. verfasserin; Kogan, Scott C. verfasserin; Rozmus, Jacob verfasserin; Le Beau, Michelle M. verfasserin; Jacks, Tyler E. verfasserin; Shannon, Kevin M. verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 101, No. 2 (2004), p. 597-602
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Type of Publication: Article
Language: English
Published: 2004
Keywords: research-article
Medical Sciences
Online: Volltext
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