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Inhibition of Ghrelin Action in vitro and in vivo by an RNA-Spiegelmer

Employing in vitro selection techniques, we have generated biostable RNA-based compounds, so-called Spiegelmers, that specifically bind n-octanoyl ghrelin, the recently discovered endogenous ligand for the type 1a growth hormone secretagogue (GHS) receptor. Ghrelin is a potent stimulant of growth... Full description

1st Person: Helmling, Steffen
Additional Persons: Maasch, Christian verfasserin; Eulberg, Dirk verfasserin; Buchner, Klaus verfasserin; Schröder, Werner verfasserin; Lange, Christian verfasserin; Vonhoff, Stefan verfasserin; Wlotzka, Britta verfasserin; Tschöp, Matthias H. verfasserin; Rosewicz, Stefan verfasserin; Klussmann, Sven verfasserin; Steiner, Donald F. verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 101, No. 36 (2004), p. 13174-13179
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Type of Publication: Article
Language: English
Published: 2004
Keywords: research-article
Online: Volltext
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