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Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopie foxp3 expression in pathogenic synovial T cells

Increasing evidence suggests that regulatory T cell (Treg) function is impaired in chronic inflammatory diseases such as rheumatoid arthritis (RA). Here we demonstrate that Tregs are unable to modulate the spontaneous production of TNF-α from RA synovial cells cultured from the diseased synovium... Full description

1st Person: Beavis, Paul A.
Additional Persons: Gregory, Bernard verfasserin; Green, Patricia verfasserin; Cribbs, Adam P. verfasserin; Kennedy, Alan verfasserin; Amjadi, Parisa verfasserin; Palfreeman, Andrew C. verfasserin; Feldmann, Marc verfasserin; Brennan, Fionula M. verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 108, No. 40 (2011), p. 16717-16722
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Type of Publication: Article
Language: English
Published: 2011
Keywords: research-article
Online: Volltext
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