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Single-Molecule Enzymology of RNA: Essential Functional Groups Impact Catalysis from a Distance

The hairpin ribozyme is a minimalist paradigm for studying RNA folding and function. In this enzyme, two domains dock by induced fit to form a catalytic core that mediates a specific backbone cleavage reaction. Here, we have fully dissected its reversible reaction pathway, which comprises two... Full description

1st Person: Rueda, David
Additional Persons: Bokinsky, Gregory; Rhodes, Maria M.; Rust, Michael J.; Zhuang, Xiaowei; Walter, Nils G.; Doudna, Jennifer A.
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 101, No. 27 (2004), p. 10066-10071
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Type of Publication: Article
Language: English
Published: 2004
Online: Volltext
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