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Expression of Human Adenosine Deaminase in Mice Reconstituted with Retrovirus-Transduced Hematopoietic Stem Cells

Recombinant retroviruses encoding human adenosine deaminase (ADA; adenosine aminohydrolase, EC have been used to infect murine hematopoietic stem cells. In bone marrow transplant recipients reconstituted with the genetically modified cells, human ADA was detected in peripheral blood... Full description

1st Person: Wilson, James M.
Additional Persons: Danos, Olivier verfasserin; Grossman, Mariann verfasserin; Raulet, David H. verfasserin; Mulligan, Richard C. verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 87, No. 1 (1990), p. 439-443
More Articles
Type of Publication: Article
Language: English
Published: 1990
Keywords: research-article
Retroviral Vector
Gene Therapy
Bone Marrow Transplantation
Online: Volltext
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