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X-Ray Crystallographic Visualization of Drug-Nucleic Acid Intercalative Binding: Structure of an Ethidium-Dinucleoside Monophosphate Crystalline Complex, Ethidium: 5-iodouridylyl(3′-5′)adenosine

We have cocrystallized the drug ethidium bromide with the dinucleoside monophosphate 5-iodouridylyl(3′-5′)adenosine and have solved the three-dimensional structure to atomic resolution by x-ray crystallography. This has allowed the direct visualization of intercalative binding by this drug to... Full description

1st Person: Tsai, Chun-Che
Additional Persons: Jain, Shri C.; Sobell, Henry M.
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 72, No. 2 (1975), p. 628-632
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Type of Publication: Article
Language: English
Published: 1975
Keywords: Biochemistry
Drug-nucleic acid interactions
Intercalation
Double helix unwinding
Online: Volltext
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