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Cell Cycle-Dependent Initiation and Lineage-Dependent Abrogation of GATA-1 Expression in Pure Differentiating Hematopoietic Progenitors

The programmed activation/repression of transcription factors in early hematopoietic differentiation has not yet been explored. The DNA-binding protein GATA-1 is required for normal erythroid development and regulates erythroid-expressed genes in maturing erythroblasts. We analyzed GATA-1... Full description

1st Person: Sposi, N. M.
Additional Persons: Zon, L. I.; Care, A.; Valtieri, M.; Testa, U.; Gabbianelli, M.; Mariani, G.; Bottero, L.; Mather, C.; Orkin, S. H.; Peschle, C.
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 89, No. 14 (1992), p. 6353-6357
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Type of Publication: Article
Language: English
Published: 1992
Keywords: Cell Biology
Hematopoietic Growth Factors
Erythroid and Myeloid Development
Transcription Factors
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