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Adhesion and Incorporation of lacZ-Transduced Endothelial Cells into the Intact Capillary Wall in the Rat

Use of the capillary bed of skeletal muscle as an in vivo recipient site to transplant autologous endothelial cells that have undergone gene transfer ex vivo has considerable potential as a technique of somatic gene therapy. Here we document a previously unrecognized capacity of endothelial cells... Full description

1st Person: Messina, Louis M.
Additional Persons: Podrazik, Rachel M. verfasserin; Whitehill, Thomas A. verfasserin; Ekhterae, Daryoush verfasserin; Brothers, Thomas E. verfasserin; Wilson, James M. verfasserin; Burkel, William E. verfasserin; Stanley, James C. verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 89, No. 24 (1992), p. 12018-12022
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Type of Publication: Article
Language: English
Published: 1992
Keywords: research-article
Genetics
Gene Therapy
Skeletal Muscle
Retroviral Vectors
Capillary Endothelium
Online: Volltext
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