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MET Amplification Occurs with or without T790M Mutations in EGFR Mutant Lung Tumors with Acquired Resistance to Gefitinib or Erlotinib

In human lung adenocarcinomas harboring EGFR mutations, a second-site point mutation that substitutes methionine for threonine at position 790 (T790M) is associated with approximately half of cases of acquired resistance to the EGFR kinase inhibitors, gefitinib and erlotinib. To identify other... Full description

1st Person: Bean, James
Additional Persons: Brennan, Cameron; Shih, Jin-Yuan; Riely, Gregory; Viale, Agnes; Wang, Lu; Chitale, Dhananjay; Motoi, Noriko; Szoke, Janos; Broderick, Stephen; Balak, Marissa; Chang, Wen-Cheng; Yu, Chong-Jen; Gazdar, Adi; Pass, Harvey; Rusch, Valerie; Gerald, William; Huang, Shiu-Feng; Yang, Pan-Chyr; Miller, Vincent; Ladanyi, Marc; Yang, Chih-Hsin; Pao, William
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 104, No. 52 (2007), p. 20932-20937
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Type of Publication: Article
Language: English
Published: 2007
Keywords: Lung adenocarcinoma
XL880
Online: Volltext
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