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Two-phase dynamics of p53 in the DNA damage response

The tumor suppressor p53 mainly induces cell cycle arrest/DNA repair or apoptosis in the DNA damage response. How to choose between these two outcomes is not fully understood. We proposed a four-module model of the p53 signaling network and associated the network dynamics with cellular outcomes... Full description

1st Person: Zhang, Xiao-Peng
Additional Persons: Liu, Feng; Wang, Wei
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 108, No. 22 (2011), p. 8990-8995
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Type of Publication: Article
Language: English
Published: 2011
Online: Volltext
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