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Structure, Inhibitor, and Regulatory Mechanism of Lyp, a Lymphoid-Specific Tyrosine Phosphatase Implicated in Autoimmune Diseases

The lymphoid-specific tyrosine phosphatase (Lyp) has generated enormous interest because a single-nucleotide polymorphism in the gene (PTPN22) encoding Lyp produces a gain-of-function mutant phosphatase that is associated with several autoimmune diseases, including type I diabetes, rheumatoid... Full description

1st Person: Yu, Xiao
Additional Persons: Sun, Jin-Peng verfasserin; He, Yantao verfasserin; Guo, Xiaoling verfasserin; Liu, Sijiu verfasserin; Zhou, Bo verfasserin; Hudmon, Andy verfasserin; Zhang, Zhong-Yin verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 104, No. 50 (2007), p. 19767-19772
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Type of Publication: Article
Language: English
Published: 2007
Keywords: research-article
Crystal structure
Enzyme regulation
Lyp inhibitor
Phosphorylation
Online: Volltext
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