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Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1

GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells, shuttles lipoprotein lipase (LPL) from subendothelial spaces to the capillary lumen. An absence of GPIHBP1 prevents the entry of LPL into capillaries, blocking LPL-mediated triglycéride hydrolysis and... Full description

1st Person: Voss, Constance V.
Additional Persons: Davies, Brandon S. J. verfasserin; Tat, Shelly verfasserin; Gin, Peter verfasserin; Fong, Loren G. verfasserin; Pelletier, Christopher verfasserin; Mottler, Charlene D. verfasserin; Bensadoun, André verfasserin; Beigneux, Anne P. verfasserin; Young, Stephen G. verfasserin; Ginsburg, David verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 108, No. 19 (2011), p. 7980-7984
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Type of Publication: Article
Language: English
Published: 2011
Keywords: research-article
Online: Volltext
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