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Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

Endoplasmatic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme involved in trimming of peptides to an optimal length for presentation by major histocompatibility complex (MHC) class I molecules. Polymorphisms in ERAP1 have been associated with chronic inflammatory diseases,... Full description

1st Person: Kochan, Grazyna
Additional Persons: Krojer, Tobias verfasserin; Harvey, David verfasserin; Fischer, Roman verfasserin; Chen, Liye verfasserin; Vollmar, Melanie verfasserin; von Delft, Frank verfasserin; Kavanagh, Kathryn L. verfasserin; Brown, Matthew A. verfasserin; Bowness, Paul verfasserin; Wordsworth, Paul verfasserin; Kessler, Benedikt M. verfasserin; Oppermann, Udo verfasserin; Feldmann, Marc verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 108, No. 19 (2011), p. 7745-7750
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Type of Publication: Article
Language: English
Published: 2011
Keywords: research-article
Online: Volltext
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