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FOXO3a-Dependent Regulation of Pinki (Park6) Mediates Survival Signaling in Response to Cytokine Deprivation

Loss-of-function mutations of phosphatase/tensin homolog deleted on chromosome 10 (PTEN)-induced putative kinase 1 (Pinki) (also known as Park6) identified in familial forms of Parkinson's disease (PD) are associated with compromised mitochondrial function. Emerging data suggest that Pinki is an... Full description

1st Person: Mei, Yang
Additional Persons: Zhang, Yiru verfasserin; Yamamoto, Kazuo verfasserin; Xie, Wei verfasserin; Mak, Tak W. verfasserin; You, Han verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 106, No. 13 (2009), p. 5153-5158
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Type of Publication: Article
Language: English
Published: 2009
Keywords: research-article
apoptosis
oxidative stress
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