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Abnormal Ambient Glucose Levels Inhibit Proteoglycan Core Protein Gene Expression and Reduce Proteoglycan Accumulation during Chondrogenesis: Possible Mechanism for Teratogenic Effects of Maternal Diabetes

Using a tissue culture system based on a nearly pure population of avian precartilage mesenchymal cells, we have found that ambient glucose levels as little as 50% lower, or 100% higher, than normally present in embryonic sera are deleterious to cartilage development, as measured by the... Full description

1st Person: Leonard, Claire M.
Additional Persons: Bergman, Michael verfasserin; Frenz, Dorothy A. verfasserin; Macreery, Linda A. verfasserin; Newman, Stuart A. verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 86, No. 24 (1989), p. 10113-10117
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Type of Publication: Article
Language: English
Published: 1989
Keywords: research-article
Medical Sciences
Extracellular Matrix
Skeletal Birth Defects
Online: Volltext
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